Department of Neurogenetics and Functional Genomics

RESEARCH PROFILE

• Identification and characterization of mutations and genomic variants connected with clinical phenotypes of neurodegenerative disorders as well as muscle, neurodevelopmental, and neuropsychiatric disorders;
• Studying of molecular and cellular processes (e.g.: associated with functioning of mitochondria and mitophagy) underlying diseases from FTD spectrum caused by PGRN, MAPT, and C9orf72 mutations and variants;
• Analysis of functional basis of familial and sporadic Alzheimer’s disease, as well as mild cognitive impairment (MCI) using iPS, NES, GABA- and glutaminergic , glial cells models, and 3D organoids;
• Advanced differentia clinical diagnosis of the vast spectrum of neurodegenerative disorders;
• Searching and bioinformatic characterization of mitochondrial and nuclear genomic variants associated with elite athlete phenotype.

Lab Members

Head: prof. Cezary Żekanowski PhD, DSc

Research staff:

• Beata Borzemska PhD, DSc,
• Mariusz Berdyński PhD,
• Anna Chołoniewska PhD,
• Jakub P. Fichna PhD, 
• Katarzyna Gawęda-Walerych PhD, 
• Michalina Wężyk PhD,
• Leila Elyasi PhD,
• Adam Figarski MD,
• Natalia Mierzwa MSc

Website: https://imdik.pan.pl/en/departments/1218-department-of-neurogenetics-and-functional-genomics